Tuning the anchoring fd viruses1/13/2024 Smit, Understanding Molecular Simulation: From Algorithms to Applications, Computational Science Series, Vol. Our results are consistent with the hypothesis that the mixture of DNA-coated fd-viruses and gold nanoparticles undergoes a non-equilibrium gelation via an arrested spinodal decomposition mechanism. The spinodal decomposition leads to the formation of small clusters of bonded rods and spheres whose further diffusion and aggregation leads to the formation of a percolating network in the system. Viral host shutoff RNases include the influenza A virus polymerase acidic-X (PA-X), the herpes simplex viruses (HSV-1 and -2) virion host shutoff protein (vhs), and the Kaposi’s sarcoma-associated herpesvirus (KSHV) shutoff and exonuclease (SOX) protein and its homologs, muSOX from murine gammaherpesvirus 68 (MHV68) and BGLF5 from EpsteinBarr virus (EBV). In the experimental conditions, we find evidence of a phase separation occurring either via nucleation-and-growth or via spinodal decomposition. Specifically, we model the system as a binary mixture of hard rods and hard spheres mutually interacting via a short-range square-well attractive potential. In order to shed light on the gelation mechanism, we introduce a model closely mimicking the experimental one and we explore via Monte Carlo simulations its equilibrium phase diagram. ![]() Upon quenching below the DNA melt temperature, such a system results in a highly porous gel state, that may be developed in a new functional material of tunable porosity. It is concluded that the homeotropic ordering of liquid crystals is a signature of the presence of enveloped viruses present on surfaces and suggests new approaches to the design of nanostructured materials that incorporate viruses as well as methods that can be used to amplify the existence of nanoscopic virions into micrometer-sized domains of liquid crystal that can been optically probed. A new gel-forming colloidal system based on a binary mixture of fd-viruses and gold nanoparticles functionalized with complementary DNA single strands has been recently introduced.
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